Drool-Worthy: As Biden Urges More COVID Tests, Quick and Inexpensive Saliva Screening is Raising Hopes for a Less Disruptive School Year
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A new breed of fast, cheap, and, in most cases, accurate new COVID-19 tests could remake the fraught debate over virus outbreaks at school this fall. Using subjectsâ saliva instead of invasive nasal probes, they promise to help schools test more people, quickly find and isolate positive cases, and return students to the classroom once they test negative.
Whether schools can roll tests out effectively â and get cooperation from those who screen positive for the virus â remains to be seen.
The promise of quicker, more accurate results could bring a welcome reprieve for school districts across the country that are sending large groups of students home with suspected COVID exposure. Last month, six days into the school year in Floridaâs Palm Beach County, one in 50 students was . In California, state guidelines call for unvaccinated students who are âclose contactsâ of a person with a positive COVID test to , forcing thousands of students too young to get a vaccine to miss critical days of in-person instruction.

While the testsâ use in schools has only recently begun to rise, the technology has been in development, in many cases, for more than a year. One of the new tests, developed by , is available through a network of nationwide and counts the National Basketball Association among its users. Another test, developed at , has been championed by New Jersey , who last year called it a potential âgame-changer.â
In the K-12 world, the saliva test with arguably the most traction is one developed by the University of Illinois â it is in use by about 45 percent of the stateâs 3,859 K-12 schools, covering more than 877,000 students, the university . School health officials elsewhere, including and Washington, D.C., are also piloting it, with more districts likely to follow.
The field will likely get a huge boost after President Biden last week nearly $2 billion for schools, community health centers, and food banks to buy about 300 million rapid tests. Biden said heâd use the Defense Production Act to increase the manufacturing of rapid tests, including those that families can use at home.
âA very promising platformâ
Researchers developed the Illinois test in June 2020, and the U.S. Food and Drug Administration granted for the so-called covidSHIELD test in February. One reason researchers say saliva tests is that virus found in the saliva is more likely to have passed into patientsâ lungs, where it can do serious damage. Viral load in saliva, they say, is also significantly higher in patients with known COVID-19 risk factors, such as obesity or diabetes.
Because the new saliva tests are polymerase chain reaction or PCR tests, they can detect both the presence of the SARS-CoV-2 virus, which causes COVID-19, as well as fragments of the virus after a test subject is no longer infected.
Dr. Rebecca Lee Smith, a University of Illinois infectious disease epidemiologist, developed the studies that earned their test its emergency authorization. She said PCR tests are not only reliable, but very sensitive. And theyâre better early-warning indicators of infection.

âOur data show that saliva is one of the best ways to find people early because the virus replicates in saliva before it moves to the nasal tissues,â she said.
But saliva tests arenât without controversy. In one case earlier this year, the FDA warned that a saliva swab test developed by the California startup ââCurative some later-stage infections. It said Curativeâs tests should only be used on people who showed COVID symptoms within the prior two weeks.
In January, health agencies in Colorado, citing concerns over false negatives, said they the Curative tests. Other purveyors have tried to distance themselves from these results.
Dr. Tim Lahey, an infectious diseases physician and head of ethics at the University of Vermont Medical Center, said heâd research with a small sample of patients on the Yale test, as well as a for other saliva tests. Research on the Yale test, he said, found that saliva in the samples was as accurate as nasal swabs. And the meta-analysis, he said, âshowed basically the same thing for various saliva testing approaches including the one developed at Yale.â

But he cautioned that he hadnât seen detailed analyses of âhow well the saliva technology performs in people with mild symptoms, or no symptoms at all.â
And the Yale sample was small â just nine patients. How well the test performs in larger groups âis still an open question.â But he said itâs âa very promising platformâ and heâs looking forward to seeing more data.
Lower cost, faster turnaround
Pinpointing exactly how many K-12 schools regularly test students for COVID-19 is difficult, but a few indicators suggest that testing isnât widespread. A recent found that the largest group of schools implementing testing last fall were using rapid tests mostly for symptomatic students and staff, âsince they often lacked enough tests to conduct screening testing.â Private schools were more likely to be conducting routine screenings, they found. One survey noted that about 20 percent of private K-12 schools conducted regular screenings at school.
The Illinois test costs just $20 to $30 per dose, a fraction of the typical $100 cost for a standard nasal swab test, according to SHIELD Illinois, the nonprofit that manages testing in the state. The organization is making it available for free to districts across the state, mostly thanks to in federal COVID test funding for schools.
Beth Heller, a spokesperson for , said the organization operates seven labs statewide, which cuts test turnaround time from as much as three days to less than one, on average.
A shorter turnaround time matters, especially now: With the earlier COVID-19 variants, Smith said, about 30 percent of infections happened before subjects showed symptoms. âWith Delta, it’s more like 75 percent.â
In Baltimore, where school health officials have been using the Illinois-developed test since March, weekly saliva testing has âmade parents feel comfortable sending their children backâ to school, said James Dendinger, interim director of COVID testing.
In most of the districtâs middle and high schools, students now submit to weekly saliva tests. In most elementary schools, health officials test classroom groups with nasal swabs. If any group of swabs delivers a positive result, they test each student again. Only those who test positive or who had close contact with those who test positive must quarantine.
These protocols kept Baltimoreâs positivity rate extremely low last spring: from March 1 to June 15, it was 0.6 percent in middle schools and high schools, and less than 0.3 percent in pre-K-8 schools.

The new tests also bring a certain comfort factor, Illinoisâ Smith said. âIt’s a lot easier to than to have a swab stuck up your nose, especially if you’re going to be testing regularly.â
Laura Wand, an advisor for SHIELD T3, the for-profit that administers the tests outside of Illinois, said that ease allows users to make testing part of their routine. âThe key to containing the virus is to be able to test often, isolate, and track,â she said. âAnd the gold standard for testing often is everybody, twice a week. Now, people are not going to do a nasal swab twice a week.â
For the SHIELD test, subjects let saliva pool in their mouth and simply raise a small funnel to their lips, then âlet the saliva fall out, push it out with your tongue,â Smith said. âOnce people get the hang of it, most people can complete the process in one to two minutes.â
One drawback: Test subjects canât have anything in their mouth for at least an hour before the test, âwhich requires planning and logistics,â especially in K-12 schools. Students canât eat or drink, chew gum, use mouthwash, or brush their teeth for at least an hour prior to the test. For adults, that means no smoking or chewing tobacco either.
Smith said the University of Illinois Urbana-Champaign, the systemâs flagship campus, relied on the test for the entire academic year, at least for the more than 35,000 students attending class in person. âWe did have some outbreaks, but they came in back under control,â she said.
The biggest one came early, between Aug. 15 and Sept. 15, 2020, as students returned to campus. In early September, the university even imposed a brief lockdown, The New York Times , after an unexpectedly high number of students with positive results continued to socialize and attend parties. One official called the phenomenon âwillful noncompliance by a small group of people,â and top officials circulated a , saying the irresponsible students âhave created the very real possibility of ending an in-person semester for all of us.â
The letter concluded, âWe stay together. Or we go home.â

Behind the scenes, though, the university was testing so often, Smith said, that âwe didn’t have to have a long-term lockdownâ like .
Willful noncompliance notwithstanding, the universityâs seven-day average positivity rate never rose above 1.21 percent, according to data on its .
Once the twice-weekly testing got underway, Smith said, this âjust brought everything back under control. We saw outbreaks within dorms or within apartment buildings, and we would increase the frequency of testing to every other day. And within a week we would bring the case numbers in that location down to zero.â
SHIELD Illinoisâ Heller said the testing regimen has allowed Champaign County, where the flagship campus is located, to keep its COVID positivity rate under 1 percent since September 2020. Elsewhere in Illinois, she said, positivity rates jumped as high as 12 percent last fall. Nationwide, positivity rates climbed to about .
The state health department in August said it would for free to any school district outside of Chicago that wanted it (The city receives a separate federal funding stream that other districts donât.) The department also said schools could use it to take advantage of a so-called âTest-to-Stayâ protocol, rather than quarantine.
Under the protocol, students and teachers who have close contact with someone who tests positive can stay in school if they agree to be tested four times: one, three, five, and seven days after exposure. If their tests remain negative, they donât have to quarantine.
Quick results bring âan extra layer of comfortâ
One of the first public school systems to take up the SHIELD tests was the tiny Hillside District 93, a pre-K-through-8 district in Cook County, about 20 minutes west of Chicago.
Superintendent Kevin Suchinski said the quick test âallowed us to make sure that we kept our doors openâ and avoid shutting down, even as other districts took to control outbreaks.
And as in many areas, COVID cases there are rising â last week, the average daily new case count per 100,000 people, but the countyâs infection rate remains among the lowest statewide.
The ease of testing studentsâ saliva, he said, meant âwe were testing early-childhood kids all the way up to 8th grade,â ages 3 to 13. The quick results, even with asymptomatic students, âgave us an extra layer of comfort to say, âIs it spreading within our community? Is it spreading within our school?â And we could then react.â
Suchinski made the tests voluntary for students and staff, but the ease of testing and the districtâs 0.5 percent positivity rate encouraged more people, including studentsâ family members, to submit to it. In August, the district was testing 55 to 60 percent of families.
âNothing’s 100 percent,â he said. âWe cannot guarantee that we’re going to stop [COVID]. We’re not going to stop cases. What we’re going to do is prevent the spread.â
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